Growth of feline panleukopenia virus and canine parvovirus in vitro

Susceptibility of several cell cultures to the feline panleukopenia virus TU 1 strain and canine parvovirus Cp49 strain was investigated. All the feline cell cultures supported the replication of both strains, but the canine cells did only that of Cp49 strain. Contrary to expectation, the evidence for positive growth of TU 1 strain in some strains of Madin-Darby canine kidney (MDCK) cells was obtained when the inoculated cells were serially subcultured. However, TU 1 strain passaged 10 times in MDCK cells did not gain the ability to infect other canine cells.