Precocious Puberty Resulting from Congenital Hypothalamic Hamartoma: Persistent Darkened Areolae After Birth as the Hallmark of Estrogen Excess

Central precocious puberty due to congenital hypothalamic hamartoma may cause isosexual precocity from early infancy. To emphasize the importance of early diagnosis of this disease, Arisaka et al present a patient in whom persistent darkened areolae from birth, a hallmark of estrogen excess, was ove...

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Veröffentlicht in:	Clinical pediatrics 2001-03, Vol.40 (3), p.163-167
Hauptverfasser:	Arisaka, Osamu, Negishi, Masao, Numata, Michio, Hoshi, Megumi, Kanazawa, Sanae, Oyama, Mariko, Nitta, Akihisa, Suzumuara, Hiroshi, Kuribayashi, Takeo, Nakayama, Yuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Body Height Brain - pathology Child development Child, Preschool Complications and side effects Diagnosis Endocrinopathies Estradiol - blood Estrogens Female Gonadotropin-Releasing Hormone - therapeutic use Gynecology. Andrology. Obstetrics Hamartoma Hamartoma - complications Hamartoma - congenital Humans Hypothalamic Diseases - complications Hypothalamic Diseases - congenital Hypothalamus. Hypophysis. Epiphysis (diseases) Magnetic Resonance Imaging Medical diagnosis Medical disorders Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Pediatrics Physical growth Precocious puberty Puberal and climacteric disorders (male and female) Puberty, Precocious - diagnosis Puberty, Precocious - drug therapy Puberty, Precocious - etiology Skin Pigmentation
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Zusammenfassung:	Central precocious puberty due to congenital hypothalamic hamartoma may cause isosexual precocity from early infancy. To emphasize the importance of early diagnosis of this disease, Arisaka et al present a patient in whom persistent darkened areolae from birth, a hallmark of estrogen excess, was overlooked.
ISSN:	0009-9228 1938-2707
DOI:	10.1177/000992280104000307