A meta-analysis of thromboembolic prophylaxis in total knee arthroplasty

A meta-analysis of thromboembolic prophylaxis in total knee arthroplasty

Deep venous thrombosis (DVT) is common in total knee arthroplasty (TKA). Because of the rarity of the most serious outcomes, most randomized controlled trials lack the power to analyze these outcomes. A meta-analysis was performed for agents used in DVT prophylaxis in TKA employing a Medline literat...

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Veröffentlicht in:The Journal of arthroplasty 2001-04, Vol.16 (3), p.293-300
Hauptverfasser: Brookenthal, K.R., Freedman, K.B., Lotke, P.A., Fitzgerald, R.H., Lonner, J.H.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Arthroplasty, Replacement, Knee
Aspirin - therapeutic use
Female
Heparin, Low-Molecular-Weight - therapeutic use
Humans
Male
meta-analysis
Postoperative Complications - prevention & control
Randomized Controlled Trials as Topic
thromboembolic disease
total knee arthroplasty
Venous Thrombosis - prevention & control
Warfarin - therapeutic use
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Zusammenfassung:Deep venous thrombosis (DVT) is common in total knee arthroplasty (TKA). Because of the rarity of the most serious outcomes, most randomized controlled trials lack the power to analyze these outcomes. A meta-analysis was performed for agents used in DVT prophylaxis in TKA employing a Medline literature search. Study inclusion criteria were randomized controlled trials comparing prophylactic agents in elective TKA with mandatory screening for DVT by venography. Fourteen studies (3,482 patients) met inclusion criteria. For total DVT, all agents except dextran and aspirin protected significantly better than placebo (P
ISSN:0883-5403
1532-8406
DOI:10.1054/arth.2001.21499