In-vitro activity of coumermycin against methicillin-resistant staphylococci: a comparison with six other agents

The in-vitro activity of coumermycin was compared with that of vancomycin, rifampicin, fusidic acid, trimethoprim-sulphamethoxazole, norfloxacin and cefamandole against seven isolates of methicillin-resistant Staphylococcus aureus and 97 isolates of methicillin-resistant coagulase negative staphyloc...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1986-08, Vol.18 (2), p.171-175
Hauptverfasser:	Thomas, Mark G., Lang, Selwyn D. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminocoumarins Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Coagulase - analysis Coumarins - pharmacology Medical sciences Methicillin - pharmacology Penicillin Resistance Pharmacology. Drug treatments Staphylococcus Staphylococcus - drug effects Staphylococcus aureus - drug effects Staphylococcus epidermidis Staphylococcus epidermidis - drug effects
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Zusammenfassung:	The in-vitro activity of coumermycin was compared with that of vancomycin, rifampicin, fusidic acid, trimethoprim-sulphamethoxazole, norfloxacin and cefamandole against seven isolates of methicillin-resistant Staphylococcus aureus and 97 isolates of methicillin-resistant coagulase negative staphylococci. Apart from one strain of methicillin-resistant S. aureus all isolates were inhibited by ≤0.06 mg/l of coumermycin. Cefamandole was more active against strains of S. epidermidis than against other coagulase negative staphylococci.
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/18.2.171