Studies on the Biosynthesis of Epothilones: The PKS and Epothilone C/D Monooxygenase

Nonproducer mutants support the assumption that epothilones A and B are synthesized by the same polyketide synthase (PKS). The endproducts of the PKS, epothilones C and D, compete for the active site of a constitutively synthesized monooxygenase which is regulated by product inhibition. The postulat...

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Veröffentlicht in:	Journal of antibiotics 2001/02/25, Vol.54(2), pp.144-148
Hauptverfasser:	GERTH, KLAUS, STEINMETZ, HEINRICH, HÖFLE, GERHARD, REICHENBACH, HANS
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Binding Sites Biological and medical sciences Epothilones Epoxy Compounds - metabolism Fundamental and applied biological sciences. Psychology General aspects Microbiology Multienzyme Complexes - metabolism Mutation Oxygenases - metabolism Proteobacteria - genetics Proteobacteria - metabolism Thiazoles - metabolism
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Beschreibung
Zusammenfassung:	Nonproducer mutants support the assumption that epothilones A and B are synthesized by the same polyketide synthase (PKS). The endproducts of the PKS, epothilones C and D, compete for the active site of a constitutively synthesized monooxygenase which is regulated by product inhibition. The postulated C-13 hydroxy-epothilones as direct precursors of epothilones C and D were not detected.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.54.144