Species-dependent differences of the biochemical properties of diamine oxidase
1. 1. Diamine oxidase (DAO) from tissues of mice, rats and humans showed different properties with respect to stability and kinetic parameters. DAO-activities in homogenates of rat or human tissues, but not of mouse tissues, rapidly decreased upon storage at −20°C. 2. 2. The K m -value for putrescin...
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| Veröffentlicht in: | International journal of biochemistry 1986, Vol.18 (9), p.835-839 |
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| container_end_page | 839 |
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| container_issue | 9 |
| container_start_page | 835 |
| container_title | International journal of biochemistry |
| container_volume | 18 |
| creator | Romijn, J.C. Verkoelen, C.F. Splinter, T.A.W. |
| description | 1.
1. Diamine oxidase (DAO) from tissues of mice, rats and humans showed different properties with respect to stability and kinetic parameters. DAO-activities in homogenates of rat or human tissues, but not of mouse tissues, rapidly decreased upon storage at −20°C.
2.
2. The
K
m
-value for putrescine was 90 μM in mouse kidney or intestine. In rats different
K
m
-values were observed before (272 μM) and after freezing (102 μM).
3.
3. A similar effect was observed with DAO in human kidney (321 and 39 μM, respectively).
4.
4. Treatment of rats with heparin resulted in a depletion of intestinal DAO and the concomitant appearance of DAO in blood.
5.
5. The enzyme remaining in the intestine showed the lower
K
m
-value. |
| doi_str_mv | 10.1016/0020-711X(86)90061-3 |
| format | Article |
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1. Diamine oxidase (DAO) from tissues of mice, rats and humans showed different properties with respect to stability and kinetic parameters. DAO-activities in homogenates of rat or human tissues, but not of mouse tissues, rapidly decreased upon storage at −20°C.
2.
2. The
K
m
-value for putrescine was 90 μM in mouse kidney or intestine. In rats different
K
m
-values were observed before (272 μM) and after freezing (102 μM).
3.
3. A similar effect was observed with DAO in human kidney (321 and 39 μM, respectively).
4.
4. Treatment of rats with heparin resulted in a depletion of intestinal DAO and the concomitant appearance of DAO in blood.
5.
5. The enzyme remaining in the intestine showed the lower
K
m
-value.</description><identifier>ISSN: 0020-711X</identifier><identifier>DOI: 10.1016/0020-711X(86)90061-3</identifier><identifier>PMID: 3093294</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Amine Oxidase (Copper-Containing) - metabolism ; Animals ; Carcinoma, Renal Cell - enzymology ; Cell Line ; Enzyme Stability ; Humans ; Kidney - enzymology ; Kidney Neoplasms - enzymology ; Kinetics ; Male ; Mice ; Mice, Inbred BALB C ; Rats ; Rats, Inbred Strains ; Species Specificity</subject><ispartof>International journal of biochemistry, 1986, Vol.18 (9), p.835-839</ispartof><rights>1986</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-90681493976ab8d24cbc6c33e3ab451ea6771c36e3bc92ffdbbcf72558e9b29c3</citedby><cites>FETCH-LOGICAL-c357t-90681493976ab8d24cbc6c33e3ab451ea6771c36e3bc92ffdbbcf72558e9b29c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3093294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romijn, J.C.</creatorcontrib><creatorcontrib>Verkoelen, C.F.</creatorcontrib><creatorcontrib>Splinter, T.A.W.</creatorcontrib><title>Species-dependent differences of the biochemical properties of diamine oxidase</title><title>International journal of biochemistry</title><addtitle>Int J Biochem</addtitle><description>1.
1. Diamine oxidase (DAO) from tissues of mice, rats and humans showed different properties with respect to stability and kinetic parameters. DAO-activities in homogenates of rat or human tissues, but not of mouse tissues, rapidly decreased upon storage at −20°C.
2.
2. The
K
m
-value for putrescine was 90 μM in mouse kidney or intestine. In rats different
K
m
-values were observed before (272 μM) and after freezing (102 μM).
3.
3. A similar effect was observed with DAO in human kidney (321 and 39 μM, respectively).
4.
4. Treatment of rats with heparin resulted in a depletion of intestinal DAO and the concomitant appearance of DAO in blood.
5.
5. The enzyme remaining in the intestine showed the lower
K
m
-value.</description><subject>Amine Oxidase (Copper-Containing) - metabolism</subject><subject>Animals</subject><subject>Carcinoma, Renal Cell - enzymology</subject><subject>Cell Line</subject><subject>Enzyme Stability</subject><subject>Humans</subject><subject>Kidney - enzymology</subject><subject>Kidney Neoplasms - enzymology</subject><subject>Kinetics</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Species Specificity</subject><issn>0020-711X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhbNQaq3-A4VZiS5Gk8lMMtkIUnxB0YUK7kIeNzTSeZhMRf-9qVO6dHXhnnPu40PohOBLggm7wrjAOSfk_bxmFwJjRnK6h6a79gE6jPEDYyLqkkzQhGJBC1FO0dNLD8ZDzC300Fpoh8x65yBAayBmncuGJWTad2YJjTdqlfWh6yEMflStV41vIeu-vVURjtC-U6sIx9s6Q293t6_zh3zxfP84v1nkhlZ8yAVmNSkFFZwpXduiNNowQylQpcuKgGKcE0MZUG1E4ZzV2jheVFUNQhfC0Bk6G-emaz7XEAfZ-GhgtVItdOsoOccVS2SSsRyNJnQxBnCyD75R4UcSLDfo5IaR3DCSNZN_6CRNsdPt_LVuwO5CW25Jvx51SE9-eQgyJooJmfUBzCBt5_9f8Au9WYCR</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Romijn, J.C.</creator><creator>Verkoelen, C.F.</creator><creator>Splinter, T.A.W.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Species-dependent differences of the biochemical properties of diamine oxidase</title><author>Romijn, J.C. ; Verkoelen, C.F. ; Splinter, T.A.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-90681493976ab8d24cbc6c33e3ab451ea6771c36e3bc92ffdbbcf72558e9b29c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Amine Oxidase (Copper-Containing) - metabolism</topic><topic>Animals</topic><topic>Carcinoma, Renal Cell - enzymology</topic><topic>Cell Line</topic><topic>Enzyme Stability</topic><topic>Humans</topic><topic>Kidney - enzymology</topic><topic>Kidney Neoplasms - enzymology</topic><topic>Kinetics</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Species Specificity</topic><toplevel>online_resources</toplevel><creatorcontrib>Romijn, J.C.</creatorcontrib><creatorcontrib>Verkoelen, C.F.</creatorcontrib><creatorcontrib>Splinter, T.A.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romijn, J.C.</au><au>Verkoelen, C.F.</au><au>Splinter, T.A.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Species-dependent differences of the biochemical properties of diamine oxidase</atitle><jtitle>International journal of biochemistry</jtitle><addtitle>Int J Biochem</addtitle><date>1986</date><risdate>1986</risdate><volume>18</volume><issue>9</issue><spage>835</spage><epage>839</epage><pages>835-839</pages><issn>0020-711X</issn><abstract>1.
1. Diamine oxidase (DAO) from tissues of mice, rats and humans showed different properties with respect to stability and kinetic parameters. DAO-activities in homogenates of rat or human tissues, but not of mouse tissues, rapidly decreased upon storage at −20°C.
2.
2. The
K
m
-value for putrescine was 90 μM in mouse kidney or intestine. In rats different
K
m
-values were observed before (272 μM) and after freezing (102 μM).
3.
3. A similar effect was observed with DAO in human kidney (321 and 39 μM, respectively).
4.
4. Treatment of rats with heparin resulted in a depletion of intestinal DAO and the concomitant appearance of DAO in blood.
5.
5. The enzyme remaining in the intestine showed the lower
K
m
-value.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>3093294</pmid><doi>10.1016/0020-711X(86)90061-3</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-711X |
| ispartof | International journal of biochemistry, 1986, Vol.18 (9), p.835-839 |
| issn | 0020-711X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77056101 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Amine Oxidase (Copper-Containing) - metabolism Animals Carcinoma, Renal Cell - enzymology Cell Line Enzyme Stability Humans Kidney - enzymology Kidney Neoplasms - enzymology Kinetics Male Mice Mice, Inbred BALB C Rats Rats, Inbred Strains Species Specificity |
| title | Species-dependent differences of the biochemical properties of diamine oxidase |
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