CAPURAMYCIN, A NEW NUCLEOSIDE ANTIBIOTIC: TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

A new antibiotic capuramycin was isolated from the culture filtrate of Streptomyces griseus 446-S3 by adsorption and partition column chromatography. Based on its chemical structure being an uracil nucleoside with a caprolactam substituent, this substance was named as capuramycin. This paper describ...

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Veröffentlicht in:	Journal of antibiotics 1986, Vol.39(8), pp.1047-1053
Hauptverfasser:	YAMAGUCHI, HIROSHI, SATO, SHINGO, YOSHIDA, SHIRO, TAKADA, KINJI, ITOH, MASAYOSHI, SETO, HARUO, OTAKE, NOBORU
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics Biological and medical sciences Biotechnology Chemical Phenomena Chemistry Fermentation Fundamental and applied biological sciences. Psychology General pharmacology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Medical sciences Nucleosides - isolation & purification Nucleosides - pharmacology Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Production of active biomolecules Streptomyces - classification Streptomyces - metabolism
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Zusammenfassung:	A new antibiotic capuramycin was isolated from the culture filtrate of Streptomyces griseus 446-S3 by adsorption and partition column chromatography. Based on its chemical structure being an uracil nucleoside with a caprolactam substituent, this substance was named as capuramycin. This paper describes the taxonomy of a producing organism, fermentation, isolation, characterization and biological properties of capuramycin.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.39.1047