AHPATININS, NEW ACID PROTEASE INHIBITORS CONTAINING 4-AMINO-3-HYDROXY-5-PHENYLPENTANOIC ACID

A soil isolate, Streptomyces sp. WK-142, was found to produce new acid protease inhibitors, ahpatinins A, B, D, E, F and G active against pepsin and renin. Ahpatinin C was found to be identical with pepstatin A. The structure determinations were based on mass spectral data. Four of the compounds con...

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Veröffentlicht in:	Journal of antibiotics 1986, Vol.39(8), pp.1079-1085
Hauptverfasser:	OMURA, SATOSHI, IMAMURA, NOBUTAKA, KAWAKITA, KAZUHITO, MORI, YOKO, YAMAZAKI, YUKIKO, MASUMA, ROKUROU, TAKAHASHI, YOKO, TANAKA, HARUO, HUANG, LEE-YUAN, WOODRUFF, H. BOYD
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - analysis Aspartic Acid Endopeptidases Biological and medical sciences Biotechnology Chemical Phenomena Chemistry Endopeptidases Fundamental and applied biological sciences. Psychology General pharmacology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Mass Spectrometry Medical sciences Oligopeptides - isolation & purification Other active biomolecules Pepsin A - antagonists & inhibitors Pepstatins - isolation & purification Pepstatins - pharmacology Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Production of active biomolecules Protease Inhibitors Renin - antagonists & inhibitors Streptomyces - classification Streptomyces - metabolism
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Zusammenfassung:	A soil isolate, Streptomyces sp. WK-142, was found to produce new acid protease inhibitors, ahpatinins A, B, D, E, F and G active against pepsin and renin. Ahpatinin C was found to be identical with pepstatin A. The structure determinations were based on mass spectral data. Four of the compounds contain the unusual amino acid, 4-amino-3-hydroxy-5-phenylpentanoic acid as a building component.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.39.1079