BIOSYNTHESIS OF LASALOCID A: METABOLIC INTERRELATIONSHIPS OF CARBOXYLIC ACID PRECURSORS AND POLYETHER ANTIBIOTICS

The metabolic interrelationships of isobutyrate, n-butyrate, and propionate in Streptomyces lasaliensis are established to show how these acids are used as precursors for the biosynthesis of the polyether antibiotic, lasalocid A.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1986, Vol.39(8), pp.1135-1143
Hauptverfasser:	SHERMAN, MARY M., YUE, STEVE, HUTCHINSON, C. RICHARD
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - biosynthesis Antibiotics Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Biotechnology Butyrates - metabolism Butyric Acid Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Isobutyrates Lasalocid - biosynthesis Microbiology Oxidation-Reduction Production of active biomolecules Propionates - metabolism Streptomyces - metabolism
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Beschreibung
Zusammenfassung:	The metabolic interrelationships of isobutyrate, n-butyrate, and propionate in Streptomyces lasaliensis are established to show how these acids are used as precursors for the biosynthesis of the polyether antibiotic, lasalocid A.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.39.1135