Effect of protease inhibitors combined with standard antiretroviral therapy on linear growth and weight gain in human immunodeficiency virus type 1-infected children

Children with HIV-1 infection and poor growth have a significant increase in the risk of death. We studied the effects of protease inhibitors on the height and weight of 27 HIV-1-infected children and found that in our small pilot study, protease inhibitor therapy had a positive effect on the height...

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Veröffentlicht in:	The Pediatric infectious disease journal 2001-03, Vol.20 (3), p.315-316
Hauptverfasser:	DREIMANE, Daina, NIELSEN, Karin, DEVEIKIS, Audra, BRYSON, Yvonne J, GEFFNER, Mitchell E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Body Height - drug effects Body Weight - drug effects Child Child, Preschool Drug Therapy, Combination Female Growth Disorders - etiology Growth Disorders - prevention & control HIV Infections - complications HIV Infections - drug therapy HIV Infections - immunology Humans Infant Male Medical sciences Pharmacology. Drug treatments Pilot Projects Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use Retrospective Studies Viral Load
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Beschreibung
Zusammenfassung:	Children with HIV-1 infection and poor growth have a significant increase in the risk of death. We studied the effects of protease inhibitors on the height and weight of 27 HIV-1-infected children and found that in our small pilot study, protease inhibitor therapy had a positive effect on the heights of HIV-1-infected children. Accelerated height velocity was sustained for at least 18 to 20 months.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/00006454-200103000-00020