ENHANCEMENT OF GRAFT-VERSUS-HOST REACTION AND DELAYED CUTANEOUS HYPERSENSITIVITY IN MICE BY UBENIMEX

The effect of ubenimex on graft-versus-host reaction and delayed cutaneous hypersensitivity in mice was studied. Ubenimex enhanced the graft-versus-host reaction in a dose range from 0.005 to 0.5 mg/kg. Ubenimex inhibited the aging-caused decrease of delayed cutaneous hypersensitivity to oxazolone a...

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Veröffentlicht in:	Journal of antibiotics 1986, Vol.39(8), pp.1172-1177
Hauptverfasser:	ABE, FUMINORI, HAYASHI, MICHIKO, HORINISHI, HIROO, MATSUDA, AKIRA, ISHIZUKA, MASAAKI, UMEZAWA, HAMAO
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Aging Animals Biological and medical sciences Dose-Response Relationship, Drug Graft vs Host Reaction - drug effects Hypersensitivity, Delayed - immunology Immunomodulators Leucine - analogs & derivatives Leucine - pharmacology Medical sciences Mice Mice, Inbred Strains Mitomycin Mitomycins - pharmacology Pharmacology. Drug treatments
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Zusammenfassung:	The effect of ubenimex on graft-versus-host reaction and delayed cutaneous hypersensitivity in mice was studied. Ubenimex enhanced the graft-versus-host reaction in a dose range from 0.005 to 0.5 mg/kg. Ubenimex inhibited the aging-caused decrease of delayed cutaneous hypersensitivity to oxazolone and the efficacy was greater with older mice. Ubenimex also inhibited mitomycin C and L1210-caused decreases of delayed cutaneous hypersensitivity to picryl chloride. However, the excess decrease caused by mitomycin C was not significantly altered by ubenimex.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.39.1172