Modulation of receptor mediated leukotriene release in the perfused heart

1. 1. The chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine (FMLP) induces peptide leukotriene release at concentrations of 20–25 pmol/ml 3 min after the start of FMLP infusion. 2. 2. FMLP-induced leukotriene release in rabbit hearts is not blocked by the leukotriene receptor antagonist FP...

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Veröffentlicht in:General pharmacology 1986, Vol.17 (4), p.437-440
Hauptverfasser: Lefer, Allan M., Roth, David M., Kugler, Jeffrey L., Smith, J.Bryan
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Sprache:eng
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Zusammenfassung:1. 1. The chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine (FMLP) induces peptide leukotriene release at concentrations of 20–25 pmol/ml 3 min after the start of FMLP infusion. 2. 2. FMLP-induced leukotriene release in rabbit hearts is not blocked by the leukotriene receptor antagonist FPL-55712 at concentrations that totally antagonize the hemodynamic effects of exogenously infused peptide leukotrienes. 3. 3. Moreover, propyl gallate, a lipoxygenase inhibitor, does not block FMLP-induced leukotriene release. 4. 4. However, the chemotactic peptide antagonist (Boc-Phe-Leu-Phe-Leu-Phe-OH) totally antagonized FMLP-induced leukotriene release suggesting that the release is via a different mechanism, possibly a receptor mediated event.
ISSN:0306-3623
1879-0011
DOI:10.1016/0306-3623(86)90187-4