Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions

Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kina...

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Veröffentlicht in:Endocrine reviews 2001-04, Vol.22 (2), p.153-183
Hauptverfasser: Pearson, Gray, Robinson, Fred, Beers Gibson, Tara, Xu, Bing-e, Karandikar, Mahesh, Berman, Kevin, Cobb, Melanie H.
Format: Artikel
Sprache:eng
Schlagworte:
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Enzymes and enzyme inhibitors
Extracellular signal-regulated kinase
Fundamental and applied biological sciences. Psychology
Gene disruption
Hormones
Humans
Kinases
MAP kinase
MAP Kinase Signaling System - physiology
Mitogen-Activated Protein Kinases - chemistry
Mitogen-Activated Protein Kinases - metabolism
Phosphorylation
Protein kinase C
Proteins
Signal transduction
Transferases
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Zusammenfassung:Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.
ISSN:0163-769X
1945-7189
DOI:10.1210/edrv.22.2.0428