Sustained‐Release Terbutaline in Nocturnal Asthma

Fifteen adult patients with nocturnal asthma entered a double blind study. They received single evening dose of one sustained‐release (SR) terbutaline tablet a 7.5 mg or an identical placebo tablet for 1 week, each in a randomised cross‐over fashion in addition to their usual medication. In the 12 e...

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Veröffentlicht in:	Allergy (Copenhagen) 1986-05, Vol.41 (4), p.308-310
Hauptverfasser:	Westermann, C. J. J., Weelden, B. M.van, Laros, C. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Asthma - drug therapy Biological and medical sciences Circadian Rhythm Clinical Trials as Topic Delayed-Action Preparations Double-Blind Method Female Humans Male Medical sciences Middle Aged nocturnal asthma Pharmacology. Drug treatments Respiratory system sustained‐release terbutaline Terbutaline - administration & dosage
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Beschreibung
Zusammenfassung:	Fifteen adult patients with nocturnal asthma entered a double blind study. They received single evening dose of one sustained‐release (SR) terbutaline tablet a 7.5 mg or an identical placebo tablet for 1 week, each in a randomised cross‐over fashion in addition to their usual medication. In the 12 evaluated patients there was no change in evening PEF but a significant improvement in morning PEF P < 0.05) and in overnight fall of PEF (P < 0.01) on active treatment. Symptoms improved by both placebo and active medication. Three patients experienced tremor as a side effect. A single evening dose of SR‐terbutaline can be of help in nocturnal asthma.
ISSN:	0105-4538 1398-9995
DOI:	10.1111/j.1398-9995.1986.tb02034.x