Pitfalls in the use of thyrotropin concentration as a first-line thyroid-function test

Measurement of thyrotropin concentration alone as a first-line thyroid-function test fails to indicate hypopituitarism in a number of patients. Using a combination of thyrotropin and thyroxine assays, we analysed 56 000 tests for a population of 471 000 over 12 months. 15 patients with clinically un...

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Veröffentlicht in:	The Lancet (British edition) 2001-03, Vol.357 (9261), p.1013-1014
Hauptverfasser:	Wardle, Catherine A, Fraser, William D, Squire, Christine R
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Biological and medical sciences Drug therapy Endocrinopathies Female Functional investigation of endocrine glands and genital system Hormones Humans Hypopituitarism Hypopituitarism - diagnosis Hypothalamus. Hypophysis. Epiphysis (diseases) Hypothyroidism Hypothyroidism - diagnosis Investigative techniques, diagnostic techniques (general aspects) Laboratories Male Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Patients Pituitary gland Prospective Studies Studies Thyroid Thyroid Function Tests Thyroid gland Thyroid-stimulating hormone Thyrotropin - blood Thyroxine Thyroxine - blood Tumors
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Zusammenfassung:	Measurement of thyrotropin concentration alone as a first-line thyroid-function test fails to indicate hypopituitarism in a number of patients. Using a combination of thyrotropin and thyroxine assays, we analysed 56 000 tests for a population of 471 000 over 12 months. 15 patients with clinically unsuspected hypopituitarism were detected, indicating that the occurrence of hypopituitarism might be underestimated.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(00)04248-3