Ketanserin and the cardiovascular system. 1. Modification of the effects of pressor amines in patients undergoing myocardial revascularisation

The effect of 10 mg of ketanserin on the pressor responses to noradrenaline, phenylephrine and angiotensin II in 19 patients during cardiopulmonary bypass was observed. The results were compatible with the previously reported evidence that ketanserin, in addition to its antagonism of serotonin, caus...

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Veröffentlicht in:	Anaesthesia 1986-07, Vol.41 (7), p.708-711
Hauptverfasser:	Griffiths, H B, Whitwam, J G
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Antihypertensive Agents - pharmacology Cardiopulmonary Bypass Drug Evaluation Hemodynamics - drug effects Humans Ketanserin Middle Aged Myocardial Revascularization Norepinephrine - pharmacology Phenylephrine - pharmacology Piperidines - pharmacology
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Zusammenfassung:	The effect of 10 mg of ketanserin on the pressor responses to noradrenaline, phenylephrine and angiotensin II in 19 patients during cardiopulmonary bypass was observed. The results were compatible with the previously reported evidence that ketanserin, in addition to its antagonism of serotonin, causes alpha 1 adrenoceptor blockade.
ISSN:	0003-2409 1365-2044
DOI:	10.1111/j.1365-2044.1986.tb12836.x