Possible modes of action of the artemisinin-type compounds

Artemisinin-type compounds are used for the treatment of uncomplicated and severe forms of malaria. They reduce parasitaemia more rapidly than any other antimalarial compound known, and are effective against multidrug-resistant parasites. However, uncertainties remain as to how they act on the paras...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Trends in parasitology 2001-03, Vol.17 (3), p.122-126
Hauptverfasser:	Olliaro, Piero L, Haynes, Richard K, Meunier, Bernard, Yuthavong, Yongyuth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - chemistry Antimalarials - pharmacology Antiparasitic agents artemisinin based compounds Artemisinins Biological and medical sciences carbon-centred radical haem haemozoin Humans malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Medical sciences open hydroperoxide peroxide bridge Pharmacology. Drug treatments Plasmodium falciparum - drug effects Sesquiterpenes - chemistry Sesquiterpenes - pharmacology trioxane pharmacophore
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Artemisinin-type compounds are used for the treatment of uncomplicated and severe forms of malaria. They reduce parasitaemia more rapidly than any other antimalarial compound known, and are effective against multidrug-resistant parasites. However, uncertainties remain as to how they act on the parasite and cause toxicity. In this review, we summarize current ideas.
ISSN:	1471-4922 1471-5007
DOI:	10.1016/S1471-4922(00)01838-9