The potential of nucleic acid repair in functional genomics

Chimeric RNA/DNA oligonucleotides have been used successfully to correct point and frameshift mutations in cells as well as in animal and plant models. This approach is one of several nucleic acid repair technologies that will help elucidate the function of newly discovered genes. Understanding the...

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Veröffentlicht in:	Nature biotechnology 2001-04, Vol.19 (4), p.321-326
Hauptverfasser:	Kmiec, Eric B, Rice, Michael C, Czymmek, Kirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Deoxyribonucleic acid Diverse techniques DNA DNA - chemistry DNA Damage DNA Repair Fundamental and applied biological sciences. Psychology Genes Genome Genomics Life Sciences Models, Genetic Molecular and cellular biology Mutation Nucleic acids Nucleic Acids - chemistry Oligonucleotides - metabolism Plasmids - metabolism Publishing Recombinant Fusion Proteins - chemistry review-article RNA - chemistry Saccharomyces cerevisiae - metabolism Stem cells
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Beschreibung
Zusammenfassung:	Chimeric RNA/DNA oligonucleotides have been used successfully to correct point and frameshift mutations in cells as well as in animal and plant models. This approach is one of several nucleic acid repair technologies that will help elucidate the function of newly discovered genes. Understanding the mechanisms by which these different technologies direct gene alteration is essential for progress in their application to functional genomics.
ISSN:	1087-0156 1546-1696
DOI:	10.1038/86701