NMDA glutamate receptor stimulation is required for the expression of D2 dopamine mediated responses in apomorphine primed 6-hydroxydopamine lesioned rats

Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-...

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Veröffentlicht in:	Brain research 2001-04, Vol.897 (1), p.213-216
Hauptverfasser:	Pollack, Alexia E., Haisley, Emily C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apomorphine Apomorphine - pharmacology Behavior, Animal - drug effects Biological and medical sciences Brain Chemistry - drug effects c-Fos Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors D2 Dopamine receptor Denervation Dizocilpine Maleate - pharmacology Dopamine Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Male NMDA Glutamate receptor Oxidopamine Parkinson Disease - drug therapy Parkinson Disease - metabolism Piperazines - pharmacology Priming Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Sprague-Dawley Receptors, Dopamine D2 - biosynthesis Receptors, Dopamine D2 - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Sympatholytics Vertebrates: nervous system and sense organs
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Zusammenfassung:	Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenuates these quinpirole-mediated responses. These findings suggest that concomitant NMDA receptor stimulation is required for the expression of D2-mediated responses in apomorphine primed dopamine-depleted rats.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(01)02086-8