Microbial Transformation of Hypoestenone

Preparative-scale fermentation of hypoestenone (1) with Mucor raman nianus (ATCC 9628) has resulted in the isolation of 8(9)α-epoxyhypoestenone (2) and the new metabolites 8(9)α-epoxy-12,13-anhydrohypoestenone (3), 17-hydroxyhypoestenone (4), 13α,18-dihydroxyhypoestenone (5), and 13β,18-dihydroxyhyp...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2001-03, Vol.64 (3), p.373-375
1. Verfasser:	El Sayed, Khalid A
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotransformation Diterpenes - chemistry Diterpenes - metabolism Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Magnoliopsida Methods. Procedures. Technologies Mucor - metabolism Plant Extracts - metabolism
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Zusammenfassung:	Preparative-scale fermentation of hypoestenone (1) with Mucor raman nianus (ATCC 9628) has resulted in the isolation of 8(9)α-epoxyhypoestenone (2) and the new metabolites 8(9)α-epoxy-12,13-anhydrohypoestenone (3), 17-hydroxyhypoestenone (4), 13α,18-dihydroxyhypoestenone (5), and 13β,18-dihydroxyhypoestenone (6). Structure elucidation of these metabolites was based primarily on 1D and 2D NMR analyses.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0005255