Lkm3 Autoantibodies in Hepatitis C Cirrhosis: A Further Phenomenon of The Hcv-Induced Autoimmunity
Chronic hepatitis C is frequently associated with laboratory markers—including LKM1 autoantibodies—of autoimmunity. A 62-yr-old woman with hepatitis C cirrhosis presented autoantibodies against liver and kidney microsomal proteins. By further evaluation of autoantibodies using ELISA and immunoblotti...
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| Veröffentlicht in: | The American journal of gastroenterology 2001-03, Vol.96 (3), p.910-911 |
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| container_title | The American journal of gastroenterology |
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| creator | Csepregi, Antal Nemesánszky, Elemér Luettig, Birgit Obermayer-Straub, Petra Manns, Michael Peter |
| description | Chronic hepatitis C is frequently associated with laboratory markers—including LKM1 autoantibodies—of autoimmunity. A 62-yr-old woman with hepatitis C cirrhosis presented autoantibodies against liver and kidney microsomal proteins. By further evaluation of autoantibodies using ELISA and immunoblotting LKM1 and LKM3 autoantibodies could be revealed. The target antigen of LKM3 autoantibodies proved to be UGT-1.1 isoenzyme. In the absence of chronic hepatitis D infection or autoimmune hepatitis type 2, this is the first case that reports the occurrence of LKM3 autoantibodies in HCV-induced chronic liver disease. |
| doi_str_mv | 10.1111/j.1572-0241.2001.03383.x |
| format | Article |
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A 62-yr-old woman with hepatitis C cirrhosis presented autoantibodies against liver and kidney microsomal proteins. By further evaluation of autoantibodies using ELISA and immunoblotting LKM1 and LKM3 autoantibodies could be revealed. The target antigen of LKM3 autoantibodies proved to be UGT-1.1 isoenzyme. In the absence of chronic hepatitis D infection or autoimmune hepatitis type 2, this is the first case that reports the occurrence of LKM3 autoantibodies in HCV-induced chronic liver disease.</description><identifier>ISSN: 0002-9270</identifier><identifier>EISSN: 1572-0241</identifier><identifier>DOI: 10.1111/j.1572-0241.2001.03383.x</identifier><identifier>PMID: 11280576</identifier><language>eng</language><publisher>Oxford: .</publisher><subject>Autoantibodies - analysis ; Autoantibodies - immunology ; Autoimmunity ; Biological and medical sciences ; Female ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Glucuronosyltransferase - immunology ; Hepatitis C - complications ; Hepatitis C - immunology ; Humans ; Liver Cirrhosis - immunology ; Liver Cirrhosis - virology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Middle Aged ; Other diseases. 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A 62-yr-old woman with hepatitis C cirrhosis presented autoantibodies against liver and kidney microsomal proteins. By further evaluation of autoantibodies using ELISA and immunoblotting LKM1 and LKM3 autoantibodies could be revealed. The target antigen of LKM3 autoantibodies proved to be UGT-1.1 isoenzyme. In the absence of chronic hepatitis D infection or autoimmune hepatitis type 2, this is the first case that reports the occurrence of LKM3 autoantibodies in HCV-induced chronic liver disease.</description><subject>Autoantibodies - analysis</subject><subject>Autoantibodies - immunology</subject><subject>Autoimmunity</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Glucuronosyltransferase - immunology</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - immunology</subject><subject>Humans</subject><subject>Liver Cirrhosis - immunology</subject><subject>Liver Cirrhosis - virology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. 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Liver. Pancreas. Abdomen</topic><topic>Glucuronosyltransferase - immunology</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - immunology</topic><topic>Humans</topic><topic>Liver Cirrhosis - immunology</topic><topic>Liver Cirrhosis - virology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. 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| subjects | Autoantibodies - analysis Autoantibodies - immunology Autoimmunity Biological and medical sciences Female Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Glucuronosyltransferase - immunology Hepatitis C - complications Hepatitis C - immunology Humans Liver Cirrhosis - immunology Liver Cirrhosis - virology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Middle Aged Other diseases. Semiology |
| title | Lkm3 Autoantibodies in Hepatitis C Cirrhosis: A Further Phenomenon of The Hcv-Induced Autoimmunity |
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