Lkm3 Autoantibodies in Hepatitis C Cirrhosis: A Further Phenomenon of The Hcv-Induced Autoimmunity

Chronic hepatitis C is frequently associated with laboratory markers—including LKM1 autoantibodies—of autoimmunity. A 62-yr-old woman with hepatitis C cirrhosis presented autoantibodies against liver and kidney microsomal proteins. By further evaluation of autoantibodies using ELISA and immunoblotting LKM1 and LKM3 autoantibodies could be revealed. The target antigen of LKM3 autoantibodies proved to be UGT-1.1 isoenzyme. In the absence of chronic hepatitis D infection or autoimmune hepatitis type 2, this is the first case that reports the occurrence of LKM3 autoantibodies in HCV-induced chronic liver disease.