Mouse beta-interferon reduces RNA efflux from isolated nuclei

Treatments of isolated L929 cell nuclei with MuIFN-beta reduced the energy-dependent efflux of 3H-RNA from these nuclei in a dose-dependent manner. These observations provide evidence for a direct physiological effect of IFN on the cell nucleus.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of interferon research 1986-06, Vol.6 (3), p.247-250
Hauptverfasser:	MACDONALD, H. S, KUSHNARYOV, V. M, HEVNER, R, SEDMAK, J. J, GROSSBERG, S. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Biological Transport, Active - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology interferon Interferon Type I - pharmacology L cells L Cells (Cell Line) - drug effects L Cells (Cell Line) - metabolism Mice Miscellaneous nuclei Regulatory factors and their cellular receptors RNA RNA - metabolism
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Beschreibung
Zusammenfassung:	Treatments of isolated L929 cell nuclei with MuIFN-beta reduced the energy-dependent efflux of 3H-RNA from these nuclei in a dose-dependent manner. These observations provide evidence for a direct physiological effect of IFN on the cell nucleus.
ISSN:	0197-8357 2332-4007
DOI:	10.1089/jir.1986.6.247