Electron capture dissociation of gaseous multiply charged ions by fourier-transform ion cyclotron resonance

Electron capture dissociation of gaseous multiply charged ions by fourier-transform ion cyclotron resonance

Fourier-transform ion cyclotron resonance instrumentation is uniquely applicable to an unusual new ion chemistry, electron capture dissociation (ECD). This causes nonergodic dissociation of far larger molecules (42 kDa) than previously observed (10 kDa) ions give far more extensive ECD if they are f...

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Veröffentlicht in:Journal of the American Society for Mass Spectrometry 2001-03, Vol.12 (3), p.245-249
Hauptverfasser: McLafferty, Fred W, Horn, David M, Breuker, Kathrin, Ge, Ying, Lewis, Mark A, Cerda, Blas, Zubarev, Roman A, Carpenter, Barry K
Format: Artikel
Sprache:eng
Schlagworte:
Beta decay
Chemical bonds
Cleavage
Covalent bonds
Cyclotron resonance
Cyclotrons
Electron capture
Fourier Analysis
Fourier transforms
Ions
Mass spectrometry
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Protein Conformation
Proteins
Proteins - chemistry
Proteome - analysis
Sequence Analysis, Protein
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Zusammenfassung:Fourier-transform ion cyclotron resonance instrumentation is uniquely applicable to an unusual new ion chemistry, electron capture dissociation (ECD). This causes nonergodic dissociation of far larger molecules (42 kDa) than previously observed (10 kDa) ions give far more extensive ECD if they are first thermally activated. This high specificity for covalent bond cleavage also makes ECD promising for studying the secondary and tertiary structure of gaseous protein ions caused by noncovalent bonding.
ISSN:1044-0305
1879-1123
DOI:10.1016/S1044-0305(00)00223-3