Bioactive chemical constituents from Alchornea laxiflora (benth) pax and hoffman

Quercetin-7,4′-disulphate ( 1) quercetin ( 2) quercetin-3′,4′-disulphate (3) quercetin-3,4′-diacetate ( 4) rutin ( 5) and quercetrin ( 6) were isolated from the ethyl acetate soluble fraction (ESM) of the crude methanolic leaf extract of Alchornea laxiflora. Purification of these compounds was carri...

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Veröffentlicht in:	Journal of ethnopharmacology 2001-03, Vol.74 (3), p.275-280
Hauptverfasser:	Ogundipe, O.O, Moody, J.O, Houghton, P.J, Odelola, H.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alchornea laxiflora Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Biological activity Biological and medical sciences Chemical constituents Euphorbiaceae General pharmacology Medical sciences Microbial Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Quercetin - analogs & derivatives Quercetin - chemistry Quercetin - isolation & purification Quercetin - pharmacology
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Zusammenfassung:	Quercetin-7,4′-disulphate ( 1) quercetin ( 2) quercetin-3′,4′-disulphate (3) quercetin-3,4′-diacetate ( 4) rutin ( 5) and quercetrin ( 6) were isolated from the ethyl acetate soluble fraction (ESM) of the crude methanolic leaf extract of Alchornea laxiflora. Purification of these compounds was carried out by column chromatography utilising sephadex LH 20 and various mixtures of water, methanol, ethanol and toluene as eluents. Structural elucidation was by UV, IR, 1HNMR and 13CNMR spectroscopy as well as by FAB-MS. Antimicrobial activity of isolated compounds was detected in Gram-positive, Gram-negative and fungal organisms.
ISSN:	0378-8741 1872-7573
DOI:	10.1016/S0378-8741(00)00352-4