Chemokines and disease

We examine here several diseases that are associated with inappropriate activation of the chemokine network. Detailed comment has been restricted to pathological states for which there are compelling data either from clinical observations or animal models. These include cardiovascular disease, aller...

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Veröffentlicht in:	Nature immunology 2001-02, Vol.2 (2), p.108-115
Hauptverfasser:	Gerard, Craig, Rollins, Barrett J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Arthritis, Rheumatoid - immunology Asthma - immunology Cardiovascular diseases Chemokines Chemokines - immunology Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - immunology HIV HIV Infections - immunology Human immunodeficiency virus Humans Inflammatory diseases Multiple Sclerosis - immunology Neoplasms - immunology Receptors, Chemokine - immunology Transplantation Transplantation Immunology Transplantation, Homologous Vascular Diseases - immunology
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Beschreibung
Zusammenfassung:	We examine here several diseases that are associated with inappropriate activation of the chemokine network. Detailed comment has been restricted to pathological states for which there are compelling data either from clinical observations or animal models. These include cardiovascular disease, allergic inflammatory disease, transplantation, neuroinflammation, cancer and HIV-associated disease. Discussion focuses on therapeutic directions in which the rapidly evolving chemokine field appears to be headed.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/84209