Outcomes following staged bilateral pallidotomy in advanced Parkinson's disease

The authors assessed clinical outcome for up to one year after staged bilateral pallidotomy in 14 patients with advanced PD. One year after surgery, dyskinesias were virtually abolished and there were significant reductions in "off" time (67%) and activities of daily living "off"...

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Veröffentlicht in:	Neurology 2001-03, Vol.56 (6), p.799-802
Hauptverfasser:	COUNIHAN, T. J, SHINOBU, L. A, ESKANDAR, E. N, COSGROVE, G. R, PENNEY, J. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Female Follow-Up Studies Functional Laterality - physiology Globus Pallidus - surgery Humans Male Medical sciences Middle Aged Movement - physiology Neurosurgery Parkinson Disease - physiopathology Parkinson Disease - surgery Prognosis Skull, brain, vascular surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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Beschreibung
Zusammenfassung:	The authors assessed clinical outcome for up to one year after staged bilateral pallidotomy in 14 patients with advanced PD. One year after surgery, dyskinesias were virtually abolished and there were significant reductions in "off" time (67%) and activities of daily living "off" scores (24%), as well as nonsignificant reduction in "off" motor score (39%); "on" scores were unchanged. One patient developed a visual field deficit; two had transient confusion. Staged bilateral pallidotomy improves motor function in selected patients with advanced PD.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.56.6.799