7-Alkyl- and 7-Cycloalkyl-5-aryl-pyrrolo[2,3- d]pyrimidines—potent inhibitors of the tyrosine kinase c-Src

7-Substituted-5-aryl-pyrrolo[2,3- d]pyrimidines have been prepared starting from α-bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60 c-Src with good specificity towards other tyrosine kinases (EGF-R, v-Abl). 7-Substituted-5-aryl-pyrrolo[2,3-...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-03, Vol.11 (6), p.849-852
Hauptverfasser:	Widler, Leo, Green, Jonathan, Missbach, Martin, Šuša, Mira, Altmann, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanes - chemical synthesis Alkanes - chemistry Alkanes - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology ErbB Receptors - antagonists & inhibitors Medical sciences Oncogene Proteins v-abl - antagonists & inhibitors Pharmacology. Drug treatments Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Pyrroles - chemical synthesis Pyrroles - chemistry Pyrroles - pharmacology src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism Structure-Activity Relationship
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Zusammenfassung:	7-Substituted-5-aryl-pyrrolo[2,3- d]pyrimidines have been prepared starting from α-bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60 c-Src with good specificity towards other tyrosine kinases (EGF-R, v-Abl). 7-Substituted-5-aryl-pyrrolo[2,3- d]pyrimidines have been prepared starting from α-bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60 c-Src with good specificity towards other tyrosine kinases (EGF-R, v-Abl).
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(01)00079-8