Pathophysiology of varicocele in nonhuman primates: long-term seminal and testicular changes

Varicocele was surgically induced in monkeys to study the long-term effects of the condition on seminal and testicular parameters. Sperm motility was depressed but improved after varicocelectomy. Sperm concentration was less affected, but sperm morphology showed long-term degenerative changes, i.e.,...

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Veröffentlicht in:Fertility and sterility 1986-09, Vol.46 (3), p.500-510
Hauptverfasser: Harrison, Richard M., Lewis, Ronald W., Roberts, James A.
Format: Artikel
Sprache:eng
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Zusammenfassung:Varicocele was surgically induced in monkeys to study the long-term effects of the condition on seminal and testicular parameters. Sperm motility was depressed but improved after varicocelectomy. Sperm concentration was less affected, but sperm morphology showed long-term degenerative changes, i.e., for more than 2 years. Testicular blood flow was depressed acutely but returned to normal after 2 years. Electron microscopy showed changes in the basal lamina and spermatogonia that persisted throughout the study. Left adrenalectomy, at the time of varicocele induction, did not alter the development of varicocele-related changes. The sequence of changes suggests that the effects of this experimental varicocele may be reversed in the monkey model through changes in collateral and ancillary revascularization.
ISSN:0015-0282
1556-5653
DOI:10.1016/S0015-0282(16)49594-4