Antagonism of lateral olfactory tract synaptic potentials in rat prepyriform cortex slices
Dose-response data were collected for the inhibition of the manosynaptic excitatory input onto prepyriform neurons from fibers of the rat lateral olfactory tract, using the potent antagonist of excitatory transmission, l(+)-2-amino-4-phosphonobutyrate ( l(+)-AP4), kynurenate, N-(p-chlorobenzoyl)pipe...
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| Veröffentlicht in: | Brain research 1986-08, Vol.379 (2), p.372-376 |
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| creator | Hearn, Timothy J. Ganong, Alan H. Cotman, Carl W. |
| description | Dose-response data were collected for the inhibition of the manosynaptic excitatory input onto prepyriform neurons from fibers of the rat lateral olfactory tract, using the potent antagonist of excitatory transmission,
l(+)-2-amino-4-phosphonobutyrate (
l(+)-AP4), kynurenate,
N-(p-chlorobenzoyl)piperazine-2,3-dicar☐ylate, and
N-(p-bromobenzoyl)piperazine-2,3-dicar☐ylate. Kynurenate and the piperazine derivatives blocked up to 80% of the synaptic response at doses of 1000μM, with single-affinity dose-response curves.
l(+)-AP4 blocked only 50% of the synaptic response at a dose of 1000μM, with a multicomponent dose-response curve. |
| doi_str_mv | 10.1016/0006-8993(86)90793-6 |
| format | Article |
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l(+)-2-amino-4-phosphonobutyrate (
l(+)-AP4), kynurenate,
N-(p-chlorobenzoyl)piperazine-2,3-dicar☐ylate, and
N-(p-bromobenzoyl)piperazine-2,3-dicar☐ylate. Kynurenate and the piperazine derivatives blocked up to 80% of the synaptic response at doses of 1000μM, with single-affinity dose-response curves.
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l(+)-2-amino-4-phosphonobutyrate (
l(+)-AP4), kynurenate,
N-(p-chlorobenzoyl)piperazine-2,3-dicar☐ylate, and
N-(p-bromobenzoyl)piperazine-2,3-dicar☐ylate. Kynurenate and the piperazine derivatives blocked up to 80% of the synaptic response at doses of 1000μM, with single-affinity dose-response curves.
l(+)-AP4 blocked only 50% of the synaptic response at a dose of 1000μM, with a multicomponent dose-response curve.</description><subject>2-amino-4-phosphonobutyrate</subject><subject>Aminobutyrates - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System - physiology</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - physiology</subject><subject>Evoked Potentials - drug effects</subject><subject>excitatory amino acid</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>kynurenic acid</subject><subject>Kynurenic Acid - pharmacology</subject><subject>lateral olfactory tract</subject><subject>Neural Inhibition - drug effects</subject><subject>Olfactory Pathways - drug effects</subject><subject>Olfactory Pathways - physiology</subject><subject>Olfactory system and olfaction. Gustatory system and gustation</subject><subject>Piperazines - pharmacology</subject><subject>prepyriform cortex slice</subject><subject>Rats</subject><subject>Synapses - drug effects</subject><subject>synaptic antagonis</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFqGzEQhkVpcBy3b9CADiWkh02llVZaXQLGJG3BkEt66UXI2lFR2V1tJDnEbx-5Nj4mJ42Yb35mPoS-UHJDCRXfCSGiapVi1634pohUrBIf0Jy2sq5EzclHND8h5-gipX_ly5giMzRjtGkYV3P0Zzlm8zeMPg04ONybDNH0OPTO2BziDudYCpx2o5myt3gKGcbsTZ-wH3E0GU8Rpl30LsQB2xAzvODUewvpEzpzhYPPx3eBft_fPa5-VuuHH79Wy3VlOZW56tzGyFrWoGwnWi6Fcqqpre24hA1XjXU1oaxxAMwIWlO-cVI554jswCgj2QJdHXKnGJ62kLIefLLQ92aEsE26JCohKXsXpLxpWk5UAfkBtDGkFMHpKfrBxJ2mRO_d671YvRerW6H_u9eijF0e87ebAbrT0FF26X899k2ypnfRjNanEyZVuV7tY24PGBRpzx6iTtbDaKHzEWzWXfBv7_EKA2-h6A</recordid><startdate>19860806</startdate><enddate>19860806</enddate><creator>Hearn, Timothy J.</creator><creator>Ganong, Alan H.</creator><creator>Cotman, Carl W.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19860806</creationdate><title>Antagonism of lateral olfactory tract synaptic potentials in rat prepyriform cortex slices</title><author>Hearn, Timothy J. ; Ganong, Alan H. ; Cotman, Carl W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-dfba7272e9cd684769f952ccd47eb495cf20135fee3a61214bf79fff07dea9a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>2-amino-4-phosphonobutyrate</topic><topic>Aminobutyrates - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System - physiology</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - physiology</topic><topic>Evoked Potentials - drug effects</topic><topic>excitatory amino acid</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>kynurenic acid</topic><topic>Kynurenic Acid - pharmacology</topic><topic>lateral olfactory tract</topic><topic>Neural Inhibition - drug effects</topic><topic>Olfactory Pathways - drug effects</topic><topic>Olfactory Pathways - physiology</topic><topic>Olfactory system and olfaction. Gustatory system and gustation</topic><topic>Piperazines - pharmacology</topic><topic>prepyriform cortex slice</topic><topic>Rats</topic><topic>Synapses - drug effects</topic><topic>synaptic antagonis</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hearn, Timothy J.</creatorcontrib><creatorcontrib>Ganong, Alan H.</creatorcontrib><creatorcontrib>Cotman, Carl W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hearn, Timothy J.</au><au>Ganong, Alan H.</au><au>Cotman, Carl W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antagonism of lateral olfactory tract synaptic potentials in rat prepyriform cortex slices</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1986-08-06</date><risdate>1986</risdate><volume>379</volume><issue>2</issue><spage>372</spage><epage>376</epage><pages>372-376</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Dose-response data were collected for the inhibition of the manosynaptic excitatory input onto prepyriform neurons from fibers of the rat lateral olfactory tract, using the potent antagonist of excitatory transmission,
l(+)-2-amino-4-phosphonobutyrate (
l(+)-AP4), kynurenate,
N-(p-chlorobenzoyl)piperazine-2,3-dicar☐ylate, and
N-(p-bromobenzoyl)piperazine-2,3-dicar☐ylate. Kynurenate and the piperazine derivatives blocked up to 80% of the synaptic response at doses of 1000μM, with single-affinity dose-response curves.
l(+)-AP4 blocked only 50% of the synaptic response at a dose of 1000μM, with a multicomponent dose-response curve.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3155349</pmid><doi>10.1016/0006-8993(86)90793-6</doi><tpages>5</tpages></addata></record> |
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| ispartof | Brain research, 1986-08, Vol.379 (2), p.372-376 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 2-amino-4-phosphonobutyrate Aminobutyrates - pharmacology Animals Biological and medical sciences Central Nervous System - physiology Cerebral Cortex - drug effects Cerebral Cortex - physiology Evoked Potentials - drug effects excitatory amino acid Fundamental and applied biological sciences. Psychology kynurenic acid Kynurenic Acid - pharmacology lateral olfactory tract Neural Inhibition - drug effects Olfactory Pathways - drug effects Olfactory Pathways - physiology Olfactory system and olfaction. Gustatory system and gustation Piperazines - pharmacology prepyriform cortex slice Rats Synapses - drug effects synaptic antagonis Vertebrates: nervous system and sense organs |
| title | Antagonism of lateral olfactory tract synaptic potentials in rat prepyriform cortex slices |
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