Antagonism of lateral olfactory tract synaptic potentials in rat prepyriform cortex slices

Dose-response data were collected for the inhibition of the manosynaptic excitatory input onto prepyriform neurons from fibers of the rat lateral olfactory tract, using the potent antagonist of excitatory transmission, l(+)-2-amino-4-phosphonobutyrate ( l(+)-AP4), kynurenate, N-(p-chlorobenzoyl)piperazine-2,3-dicar☐ylate, and N-(p-bromobenzoyl)piperazine-2,3-dicar☐ylate. Kynurenate and the piperazine derivatives blocked up to 80% of the synaptic response at doses of 1000μM, with single-affinity dose-response curves. l(+)-AP4 blocked only 50% of the synaptic response at a dose of 1000μM, with a multicomponent dose-response curve.