Themes and variations on ubiquitylation
Ubiquitylation--the conjugation of proteins with a small protein called ubiquitin--touches upon all aspects of eukaryotic biology, and its defective regulation is manifest in diseases that range from developmental abnormalities and autoimmunity to neurodegenerative diseases and cancer. A few years a...
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| Veröffentlicht in: | Nature reviews. Molecular cell biology 2001-03, Vol.2 (3), p.169-178 |
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| container_title | Nature reviews. Molecular cell biology |
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| creator | Weissman, Allan M |
| description | Ubiquitylation--the conjugation of proteins with a small protein called ubiquitin--touches upon all aspects of eukaryotic biology, and its defective regulation is manifest in diseases that range from developmental abnormalities and autoimmunity to neurodegenerative diseases and cancer. A few years ago, we could only have dreamt of the complex arsenal of enzymes dedicated to ubiquitylation. Why has nature come up with so many ways of doing what seems to be such a simple job? |
| doi_str_mv | 10.1038/35056563 |
| format | Article |
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| ispartof | Nature reviews. Molecular cell biology, 2001-03, Vol.2 (3), p.169-178 |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Animals Binding Sites Biology Cancer DNA repair Endoplasmic reticulum Enzymes Humans Kinases Ligases - metabolism Models, Molecular Nuclear Proteins Phosphorylation Protein Binding Protein Structure, Tertiary Proteins Proteins - chemistry Proteins - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-cbl Proto-Oncogene Proteins c-mdm2 Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Ubiquitins - metabolism |
| title | Themes and variations on ubiquitylation |
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