Themes and variations on ubiquitylation

Themes and variations on ubiquitylation

Ubiquitylation--the conjugation of proteins with a small protein called ubiquitin--touches upon all aspects of eukaryotic biology, and its defective regulation is manifest in diseases that range from developmental abnormalities and autoimmunity to neurodegenerative diseases and cancer. A few years a...

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Veröffentlicht in:Nature reviews. Molecular cell biology 2001-03, Vol.2 (3), p.169-178
1. Verfasser: Weissman, Allan M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Binding Sites
Biology
Cancer
DNA repair
Endoplasmic reticulum
Enzymes
Humans
Kinases
Ligases - metabolism
Models, Molecular
Nuclear Proteins
Phosphorylation
Protein Binding
Protein Structure, Tertiary
Proteins
Proteins - chemistry
Proteins - metabolism
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-cbl
Proto-Oncogene Proteins c-mdm2
Ubiquitin-Conjugating Enzymes
Ubiquitin-Protein Ligases
Ubiquitins - metabolism
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Zusammenfassung:Ubiquitylation--the conjugation of proteins with a small protein called ubiquitin--touches upon all aspects of eukaryotic biology, and its defective regulation is manifest in diseases that range from developmental abnormalities and autoimmunity to neurodegenerative diseases and cancer. A few years ago, we could only have dreamt of the complex arsenal of enzymes dedicated to ubiquitylation. Why has nature come up with so many ways of doing what seems to be such a simple job?
ISSN:1471-0072
1471-0080
DOI:10.1038/35056563