Systemic lupus erythematosus is not genetically linked to the beta chain of the T cell receptor

The genomic DNA polymorphism of the beta chain of the T cell receptor was examined. The restriction fragment length polymorphism distribution was similar in systemic lupus erythematosus patients, their relatives, and normal controls. Our observations suggest that these genes are not coinherited with...

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Veröffentlicht in:	Arthritis and rheumatism 1986-08, Vol.29 (8), p.1023-1025
Hauptverfasser:	Fronek, Zdenka, Lentz, Daniel, Berliner, Nancy, Duby, Allan D., Klein, Karen A., Seidman, J. G., Schur, Peter H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences DNA - genetics Humans Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Medical sciences Polymorphism, Genetic Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Zusammenfassung:	The genomic DNA polymorphism of the beta chain of the T cell receptor was examined. The restriction fragment length polymorphism distribution was similar in systemic lupus erythematosus patients, their relatives, and normal controls. Our observations suggest that these genes are not coinherited with genes responsible for systemic lupus erythematosus.
ISSN:	0004-3591 1529-0131
DOI:	10.1002/art.1780290812