Antibodies to Toxoplasma gondii in Individuals with First-Episode Schizophrenia

We employed enzyme immunoassay (EIA) and Western blotting techniques to measure the level of antibodies to Toxoplasma gondii proteins in serum samples from 38 individuals undergoing their first episode of schizophrenia and from a group of matched control subjects. We found that the individuals with...

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Veröffentlicht in:	Clinical infectious diseases 2001-03, Vol.32 (5), p.842-844
Hauptverfasser:	Yolken, Robert H., Bachmann, Silke, Rouslanova, Inna, Lillehoj, Erik, Ford, Glen, Torrey, E. Fuller, Schroeder, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Animals Antibodies Antibodies, Protozoan - blood Antibody Specificity Antigens Biological and medical sciences Blotting, Western Brief Reports Central nervous system diseases Humans Immunoenzyme Techniques Infections Infectious diseases Matched-Pair Analysis Medical sciences Mental illness Middle Aged Nervous system diseases Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reactivity Schizophrenia Schizophrenia - complications Schizophrenia - immunology Toxoplasma - immunology Toxoplasmosis - complications Toxoplasmosis - immunology
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Zusammenfassung:	We employed enzyme immunoassay (EIA) and Western blotting techniques to measure the level of antibodies to Toxoplasma gondii proteins in serum samples from 38 individuals undergoing their first episode of schizophrenia and from a group of matched control subjects. We found that the individuals with first-episode schizophrenia had significantly increased levels of IgG, IgM, and IgA class antibodies to Toxoplasma proteins, as compared with the control subjects.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/319221