A mechanism of apoptosis induced by all-trans retinoic acid on adult T-cell leukemia cells: a possible involvement of the Tax/NF-kappaB signaling pathway

In this study, five single clones were randomly established by limiting dilution method from each of the HTLV-I positive T cell lines - HUT 102 and ATL-2, and examined for the all-trans retinoic acid (ATRA) sensitivity, respectively. For each clone, we found a significant correlation between the red...

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Veröffentlicht in:	Leukemia research 2001-04, Vol.25 (4), p.323-331
Hauptverfasser:	Nawata, H, Maeda, Y, Sumimoto, Y, Miyatake, J, Kanamaru, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Annexin A5 - analysis Apoptosis - drug effects Clone Cells - drug effects DNA - biosynthesis DNA - drug effects DNA - ultrastructure DNA Fragmentation - drug effects Down-Regulation Female Gene Products, tax - metabolism Gene Products, tax - pharmacology Gene Products, tax - physiology Humans Jurkat Cells Leukemia-Lymphoma, Adult T-Cell - drug therapy Leukemia-Lymphoma, Adult T-Cell - pathology Male Methods Middle Aged NF-kappa B - drug effects NF-kappa B - physiology Receptors, Interleukin-2 - metabolism Signal Transduction - drug effects Transcription, Genetic - drug effects Transfection Tretinoin - pharmacology Tumor Cells, Cultured
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Zusammenfassung:	In this study, five single clones were randomly established by limiting dilution method from each of the HTLV-I positive T cell lines - HUT 102 and ATL-2, and examined for the all-trans retinoic acid (ATRA) sensitivity, respectively. For each clone, we found a significant correlation between the reduction in 3[H]-thymidine incorporation and the reduction in CD25 expression (r=0.701, P
ISSN:	0145-2126