Episodic secretion of ACTH in rats

Episodic secretion of ACTH in rats

While the circadian rhythm of pituitary adrenocorticotropin (ACTH) secretion has been well characterized, the ultradian rhythm has been less thoroughly investigated. To study the episodic nature of ACTH secretion, unrestrained, unanesthetized rats were bled continuously through indwelling jugular ve...

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Veröffentlicht in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1986-03, Vol.7 (2), p.219-223
Hauptverfasser: Carnes, Molly, Brownfield, Mark S., Kalin, Ned H., Lent, Stephanie, Barksdale, Charles M.
Format: Artikel
Sprache:eng
Schlagworte:
ACTH
Activity Cycles
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - metabolism
Animals
Biological and medical sciences
Circadian Rhythm
Fundamental and applied biological sciences. Psychology
Hormones and neuropeptides. Regulation
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Male
Pulsatile secretion
Radioimmunoassay
Rats
Rats, Inbred Strains
Time Factors
Ultradian rhythm
Vertebrates: endocrinology
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Zusammenfassung:While the circadian rhythm of pituitary adrenocorticotropin (ACTH) secretion has been well characterized, the ultradian rhythm has been less thoroughly investigated. To study the episodic nature of ACTH secretion, unrestrained, unanesthetized rats were bled continuously through indwelling jugular venous cannulae and blood sampled for up to 75 mintues at one-minute intervals beginning at 1100 hr ( n=6 ) or 1730 hr ( n=4 ). Sporadic low-amplitude micropulses were observed at both times of day. In addition, infrequent “superpulses” were observed in the evening. Analysis of pulse parameters revealed a significant ( p
ISSN:0196-9781
1873-5169
DOI:10.1016/0196-9781(86)90216-0