Replication checkpoint: Preventing mitotic catastrophe

A conserved network of signal transduction pathways prevents mitosis if DNA is damaged or its synthesis incomplete. Loss of this checkpoint control is detrimental to the developing embryo. Recent studies have shed new light on how the essential ATR and Chk1 protein kinases cooperate to prevent such...

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Veröffentlicht in:	Current biology 2001-02, Vol.11 (4), p.R121-R124
1. Verfasser:	Canman, Christine E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Telangiectasia Mutated Proteins ATR protein Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Cycle Proteins - physiology Checkpoint Kinase 1 Checkpoint Kinase 2 Chk1 protein DNA Damage DNA Polymerase I - metabolism DNA Replication DNA-Binding Proteins Humans Mitosis - physiology Proliferating Cell Nuclear Antigen - metabolism Protein Kinases - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Schizosaccharomyces pombe Proteins Signal Transduction - physiology Tumor Suppressor Proteins
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Beschreibung
Zusammenfassung:	A conserved network of signal transduction pathways prevents mitosis if DNA is damaged or its synthesis incomplete. Loss of this checkpoint control is detrimental to the developing embryo. Recent studies have shed new light on how the essential ATR and Chk1 protein kinases cooperate to prevent such a crisis.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/S0960-9822(01)00057-4