Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes

Rapamycin is a fungal macrolide that inhibits the proliferation of T cells. Studies in both animals and humans have found that rapamycin significantly reduces graft rejection. However, though CD8(+) T cells are involved in graft infiltration and rejection, little is known regarding the effects of ra...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-03, Vol.166 (5), p.3201-3209
Hauptverfasser:	Slavik, J M, Lim, D G, Burakoff, S J, Hafler, D A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - metabolism CD2 Antigens - immunology CD2 Antigens - metabolism CD28 Antigens - immunology CD28 Antigens - metabolism CD3 Complex - immunology CD3 Complex - metabolism CD8 Antigens - immunology CD8 Antigens - metabolism CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - enzymology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line, Transformed Clone Cells Dose-Response Relationship, Drug Dose-Response Relationship, Immunologic Drug Resistance Enzyme Activation - drug effects Enzyme Activation - immunology Epitopes, T-Lymphocyte - immunology HLA-A Antigens - physiology Humans Immunosuppressive Agents - pharmacology Interleukin-2 - physiology Lymphocyte Activation - drug effects Major Histocompatibility Complex - immunology Models, Immunological Ribosomal Protein S6 Kinases - metabolism Sirolimus - pharmacology T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - enzymology T-Lymphocyte Subsets - immunology
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