The ins and outs of nucleosome assembly

De novo nucleosome assembly coupled to DNA replication and repair in vitro involves the histone chaperone chromatin assembly factor 1 (CAF-1). Recent studies support a model in which CAF-1 can be targeted to newly synthesized DNA through a direct interaction with proliferating cell nuclear antigen (...

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Veröffentlicht in:	Current Opinion in Genetics & Development 2001-04, Vol.11 (2), p.136-141
Hauptverfasser:	Mello, Jill A, Almouzni, Geneviève
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals CAF-1 chromatin Chromatin Assembly Factor-1 Chromosomal Proteins, Non-Histone DNA - metabolism DNA Repair DNA Replication DNA-Binding Proteins - metabolism epigenetic histone modification Histones - metabolism Models, Biological Molecular Chaperones - metabolism nucleosome assembly Nucleosomes - chemistry Nucleosomes - metabolism PCNA Proliferating Cell Nuclear Antigen - metabolism replication
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Beschreibung
Zusammenfassung:	De novo nucleosome assembly coupled to DNA replication and repair in vitro involves the histone chaperone chromatin assembly factor 1 (CAF-1). Recent studies support a model in which CAF-1 can be targeted to newly synthesized DNA through a direct interaction with proliferating cell nuclear antigen (PCNA) and can act synergistically with a newly identified histone chaperone. Insights have also been obtained into mechanisms by which this CAF-1-dependent pathway can establish a repressed chromatin state.
ISSN:	0959-437X 1879-0380
DOI:	10.1016/S0959-437X(00)00170-2