RNA-based silencing strategies in plants

In plants, double-stranded RNA can silence genes by triggering degradation of homologous RNA in the cytoplasm and by directing methylation of homologous nuclear DNA sequences. Analyses of Arabidopsis mutants and plant viral suppressors of silencing are unraveling RNA-silencing mechanisms, which requ...

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Veröffentlicht in:	Current Opinion in Genetics & Development 2001-04, Vol.11 (2), p.221-227
Hauptverfasser:	Matzke, Marjori A, Matzke, Antonius J.M, Pruss, Gail J, Vance, Vicki B
Format:	Artikel
Sprache:	eng
Schlagworte:	Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis thaliana Arabodopsis mutants DNA Methylation DNA, Plant - metabolism double-stranded RNA Gene Silencing homology-dependent gene silencing posttranscriptional gene silencing Promoter Regions, Genetic quelling RNA, Antisense RNA, Double-Stranded - metabolism RNA, Messenger - biosynthesis RNA, Plant - metabolism RNA-directed DNA methylation RNAi small RNAs Transcription, Genetic transcriptional gene silencing viral suppressors
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Beschreibung
Zusammenfassung:	In plants, double-stranded RNA can silence genes by triggering degradation of homologous RNA in the cytoplasm and by directing methylation of homologous nuclear DNA sequences. Analyses of Arabidopsis mutants and plant viral suppressors of silencing are unraveling RNA-silencing mechanisms, which require common proteins in diverse organisms, and are assessing the role of methylation in transcriptional and posttranscriptional gene silencing.
ISSN:	0959-437X 1879-0380
DOI:	10.1016/S0959-437X(00)00183-0