Chromosome Mapping of the Human Arrestin (SAG), β-Arrestin 2 (ARRB2), and β-Adrenergic Receptor Kinase 2 (ADRBK2) Genes

Two types of proteins play a major role in determining homologous desensitization of G-coupled receptors: β-adrenergic receptor kinase (βARK), which phosphorylates the agonist-occupied receptor and its functional cofactor, β-arrestin. Both βARK and β-arrestin are members of multigene families. The family of G-protein-coupled receptor kinases includes rhodopsin kinase, βARK1, βARK2, IT11-A (GRK4), GRK5, and GRK6. The arrestin/β-arrestin gene family includes arrestin (also known as S-antigen), β-arrestin 1, and β-arrestin 2. Here we report the chromosome mapping of the human genes for arrestin (SAG), β-arrestin 2 (ARRB2), and βARK2 (ADRBK2) by fluorescence in situ hybridization (FISH). FISH results confirmed the assignment of the gene coding for arrestin (SAG) to chromosome 2 and allowed us to refine its localization to band q37. The gene coding for β-arrestin 2 (ARRB2) was mapped to chromosome 17p13 and that coding for βARK2 (ADRBK2) to chromosome 22q11.