The analgesic and antipyretic effects of a non-steroidal antiinflammatory agent, EB-382, in experimental animals

The analgesic and antipyretic effects of EB-382 as a new non-steroidal antiinflammatory agent were examined in mice and rats. EB-382 had an equipotent inhibition to ibuprofen on the writhing syndrome caused by acetic acid, phenylquinone and acetylcholine in mice, but phenylbutazone was less potent i...

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Veröffentlicht in:Folia Pharmacologica Japonica 1986, Vol.87(5), pp.527-536
Hauptverfasser: FUJIYOSHI, Toshio, IIDA, Hiroyuki, SAITO, Masumi, IKEDA, Kenro, YAMAURA, Tetsuaki, UEMATSU, Toshio
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Sprache:eng ; jpn
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Zusammenfassung:The analgesic and antipyretic effects of EB-382 as a new non-steroidal antiinflammatory agent were examined in mice and rats. EB-382 had an equipotent inhibition to ibuprofen on the writhing syndrome caused by acetic acid, phenylquinone and acetylcholine in mice, but phenylbutazone was less potent in these experiments. EB-382 had a much more potent inhibition on the pain by the Randall-Selitto method and silver nitrate-induced arthritic pain in rats than ibuprofen and phenylbutazone. EB-382 had no analgesic effect on the pain of nontreated foot by the Randall-Selitto method in rats and by the hot-plate method in mice. EB-382 had a much more potent inhibition on the yeast-induced chronic inflammatory andadjuvant arthritic pains in rats than ibuprofen and phenylbutazone. The antipyretic activity of EB-382 was almost equipotent to that of ibuprofen in rats. EB-382 had no effect on the normal body temperature in rats, which was different from aminopyrine. The above results suggest that EB-382 will be a useful analgesic agent with an antipyretic antiinflammatory activity in clinical studies.
ISSN:0015-5691
1347-8397
DOI:10.1254/fpj.87.527