Evaluation of coronary risk factors in patients with heterozygous familial hypercholesterolemia

Age at onset of clinically manifested coronary artery disease (CAD) varies widely among patients with familial hypercholesterolemia (FH). A number of factors in addition to high low-density lipoprotein cholesterol (LDL) have been suggested as predictors of risk among patients with FH, but a comprehe...

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Veröffentlicht in:	The American journal of cardiology 2001-03, Vol.87 (5), p.547-553
Hauptverfasser:	Hopkins, Paul N, Stephenson, Susan, Wu, Lily L, Riley, Ward A, Xin, Yuanpei, Hunt, Steven C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Apolipoproteins B - blood Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular disease Cholesterol Cholesterol, LDL - blood Coronary Disease - blood Coronary Disease - genetics Coronary Disease - prevention & control Coronary heart disease Female Genetic Carrier Screening Health risk assessment Heart Humans Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - genetics Hyperlipoproteinemia Type II - prevention & control Male Medical sciences Middle Aged Risk Factors Sex Factors
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Zusammenfassung:	Age at onset of clinically manifested coronary artery disease (CAD) varies widely among patients with familial hypercholesterolemia (FH). A number of factors in addition to high low-density lipoprotein cholesterol (LDL) have been suggested as predictors of risk among patients with FH, but a comprehensive examination of their utility is lacking. We therefore measured plasma lipids, carotid intima-medial thickness, and a variety of coronary risk factors in 262 patients with FH ≥30 years old (68 of whom had premature CAD). Age (p
ISSN:	0002-9149 1879-1913
DOI:	10.1016/S0002-9149(00)01429-6