Identical Twins Concordant for Crohnʼs Disease

Identical twin adolescent girls developed Crohnʼs disease within 15 months of each other. Clinical symptoms, growth retardation, barium studies, disease course, and pathologic findings at the time of resection were remarkably similar. Seventeen pairs of twins concordant for Crohnʼs disease have now...

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Veröffentlicht in:	Journal of clinical gastroenterology 1986-06, Vol.8 (3 Part 1), p.290-294
Hauptverfasser:	Sirlin, Scott M, Benkov, Keith J, Kazlow, Phillip, Dolgin, Stephen, Dische, M Renate, LeLeiko, Neal S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biological and medical sciences Crohn Disease - genetics Crohn Disease - pathology Crohn Disease - surgery Female Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Twins Twins, Monozygotic
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Zusammenfassung:	Identical twin adolescent girls developed Crohnʼs disease within 15 months of each other. Clinical symptoms, growth retardation, barium studies, disease course, and pathologic findings at the time of resection were remarkably similar. Seventeen pairs of twins concordant for Crohnʼs disease have now been reported, but only four discordant pairs. Such observations lend support to a considerable genetic influence on the development and course of Crohnʼs disease.
ISSN:	0192-0790 1539-2031
DOI:	10.1097/00004836-198606000-00019