Synthesis and Antiviral Evaluation of Hydantoin Analogues of AZT

3′‐Azidonucleosides 4 have been synthesized by condensation of silylated (Z)‐5‐ethylidenehydantoin and (Z)‐5‐benzylidenehydantoin with methyl 3‐azido‐5‐O‐tert‐butyldiphenylsilyl‐2,3‐dideoxy‐D‐erythro‐pentofuranoside (3). The nucleosides 4 were deblocked on treatment with tetrabutylammonium fluoride....

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 1994, Vol.327 (10), p.653-655
Hauptverfasser:	El-Barbary, Ahmed A., Khodair, Ahmed I., Pedersen, Erik B.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Carbohydrates. Nucleosides and nucleotides Chemistry Exact sciences and technology Herpesvirus 1, Human - drug effects HIV-1 - drug effects Humans Hydantoins - chemical synthesis Hydantoins - pharmacology Nucleosides, nucleotides and oligonucleotides Organic chemistry Preparations and properties Zidovudine - analogs & derivatives Zidovudine - chemical synthesis Zidovudine - pharmacology
Online-Zugang:	Volltext
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