Retinol binding protein and prealbumin in Reye's Syndrome
Retinol binding protein (RBP) and prealbumin (PA) were analyzed in 29 serum samples from 8 patients with stages II and III Reye's Syndrome (RS), and from 10 healthy fasting children. All RS patients had at least one abnormally low RBP and PA value. A return toward normal was evident within 2–3...
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Veröffentlicht in: | Clinical biochemistry 1986-06, Vol.19 (3), p.189-191 |
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Zusammenfassung: | Retinol binding protein (RBP) and prealbumin (PA) were analyzed in 29 serum samples from 8 patients with stages II and III Reye's Syndrome (RS), and from 10 healthy fasting children. All RS patients had at least one abnormally low RBP and PA value. A return toward normal was evident within 2–3 days in serial samples. The nadir RBP and PA values in RS (means of 9 and 107 mg/L) were significantly different (
p < 0.001) from those of the controls (RBP mean of 40 and PA of 157 mg/L).
A significant correlation was found between RBP and PA serum values in RS (
r = 0.7,
p < 0.001); the high admission NH
+
4 values tended to associate with low RBP levels; however, the correlation was not very high (
r = −0.4,
p < 0.01).
The presence of an abnormal vitamin A transport system at an early stage of RS raises the possibility of additional abnormalities in vitamin A metabolism in these patients. The findings of reduced serum levels of complement, clotting factors, fibronectin, and now RBP and PA, suggest a marked short-term impairment of hepatic synthesis of proteins and/or their release in RS. |
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ISSN: | 0009-9120 1873-2933 |
DOI: | 10.1016/S0009-9120(86)80022-4 |