Lack of effect of antipsychotic and antidepressant drugs on glutamate receptor mRNA levels in rat brains

By employing multiprobe oligonucleotide solution hybridisation (MOSH) we have measured the levels of mRNA encoding the NMDA receptor subtypes (R1, R2A, R2B and R2C) and the non-NMDA glutamate receptor subtypes (GluR1, 2, 3, and 4) within rat brain following, 1–32 days of antipsychotic or antidepress...

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Veröffentlicht in:	Neuroscience letters 1994-01, Vol.177 (1), p.39-43
Hauptverfasser:	Oretti, Rossana G., Spurlock, Gillian, Buckland, Paul R., McGuffin, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressant Antidepressive Agents - pharmacology Antipsychotic Antipsychotic Agents - pharmacology Base Sequence Biological and medical sciences Brain Chemistry - drug effects Citalopram - pharmacology Clozapine - pharmacology Gene Expression Regulation - drug effects Glutamate receptor gene expression Haloperidol - pharmacology Male Medical sciences Messenger RNA measurement Mianserin - pharmacology Molecular Sequence Data Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Receptors, Glutamate - biosynthesis Receptors, Glutamate - drug effects Receptors, Glutamate - genetics Receptors, N-Methyl-D-Aspartate - biosynthesis Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Schizophrenia Sulpiride - pharmacology
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Zusammenfassung:	By employing multiprobe oligonucleotide solution hybridisation (MOSH) we have measured the levels of mRNA encoding the NMDA receptor subtypes (R1, R2A, R2B and R2C) and the non-NMDA glutamate receptor subtypes (GluR1, 2, 3, and 4) within rat brain following, 1–32 days of antipsychotic or antidepressant drug administration. The results suggest that the drugs studied do not significantly alter rat glutamatergic system mRNA levels when compared to controls.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(94)90039-6