Age-Dependent Decrease in Platelet Aggregation in Rats
The degree of platelet aggregation induced by ADP and collagen was examined in platelet-rich plasma from 7-to 90-week-old rats. The aggregation induced by ADP was unchanged at 90 weeks. Collagen-induced aggregation decreased remarkably at 60 and 90 weeks. Therefore, collagen-induced platelet activat...
Gespeichert in:
| Veröffentlicht in: | Biological & pharmaceutical bulletin 1994/08/15, Vol.17(8), pp.1124-1125 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1125 |
|---|---|
| container_issue | 8 |
| container_start_page | 1124 |
| container_title | Biological & pharmaceutical bulletin |
| container_volume | 17 |
| creator | OSHIMA, Kouichi MORIKAWA, Tadanori HAGIWARA, Masaki |
| description | The degree of platelet aggregation induced by ADP and collagen was examined in platelet-rich plasma from 7-to 90-week-old rats. The aggregation induced by ADP was unchanged at 90 weeks. Collagen-induced aggregation decreased remarkably at 60 and 90 weeks. Therefore, collagen-induced platelet activation is highly age-dependent, with rats of advanced age showing a lower response than younger rats. |
| doi_str_mv | 10.1248/bpb.17.1124 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76944446</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3120250431</sourcerecordid><originalsourceid>FETCH-LOGICAL-c564t-7d4199524abdd87fdc7733ccdf5a467d90201a42cf4fb91aec525723a4ce14e53</originalsourceid><addsrcrecordid>eNpdkM1r3DAQxUVpSDZpTzkHFhJ6Kd5q9GHZxyXbtIVAQmjPYiyPHS9eeyNpD_nvI7NmD52DhtH7MW94jF0DX4FQxY9qX63ArCANn9gCpDKZFqA_swUvochy0MUFuwxhyzk3XMhzdm4KwUHAguXrlrIN7WmoaYjLDTlPGGjZDcvnHiP1FJfrtvXUYuzGYfp_wRi-sLMG-0Bf537F_j38_Hv_O3t8-vXnfv2YOZ2rmJlaQVlqobCq68I0tTNGSufqRqPKTV3ydAYq4RrVVCUgOS20ERKVI1Ck5RX7dty79-PbgUK0uy446nscaDwEa_JSpcoTePsfuB0Pfki3WVCqBK1zM1Hfj5TzYwieGrv33Q79uwVupyxtytKCsVOWib6Zdx6qHdUndg4v6XezjsFh33gcXBdOmFQcpDYJ2xyxbYjY0klHHzvX02SZQpKTbTE_yf0ku1f0lgb5AQwNkYY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449155676</pqid></control><display><type>article</type><title>Age-Dependent Decrease in Platelet Aggregation in Rats</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>OSHIMA, Kouichi ; MORIKAWA, Tadanori ; HAGIWARA, Masaki</creator><creatorcontrib>OSHIMA, Kouichi ; MORIKAWA, Tadanori ; HAGIWARA, Masaki</creatorcontrib><description>The degree of platelet aggregation induced by ADP and collagen was examined in platelet-rich plasma from 7-to 90-week-old rats. The aggregation induced by ADP was unchanged at 90 weeks. Collagen-induced aggregation decreased remarkably at 60 and 90 weeks. Therefore, collagen-induced platelet activation is highly age-dependent, with rats of advanced age showing a lower response than younger rats.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.17.1124</identifier><identifier>PMID: 7820121</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Adenosine Diphosphate - pharmacology ; ADP ; age ; Aging - blood ; Animals ; Biological and medical sciences ; Blood coagulation. Blood cells ; collagen ; Collagen - pharmacology ; Fundamental and applied biological sciences. Psychology ; Male ; Molecular and cellular biology ; Platelet ; platelet aggregation ; Platelet Aggregation - drug effects ; Platelet Aggregation - physiology ; Rats ; Rats, Wistar</subject><ispartof>Biological and Pharmaceutical Bulletin, 1994/08/15, Vol.17(8), pp.1124-1125</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1995 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3401357$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7820121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OSHIMA, Kouichi</creatorcontrib><creatorcontrib>MORIKAWA, Tadanori</creatorcontrib><creatorcontrib>HAGIWARA, Masaki</creatorcontrib><title>Age-Dependent Decrease in Platelet Aggregation in Rats</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The degree of platelet aggregation induced by ADP and collagen was examined in platelet-rich plasma from 7-to 90-week-old rats. The aggregation induced by ADP was unchanged at 90 weeks. Collagen-induced aggregation decreased remarkably at 60 and 90 weeks. Therefore, collagen-induced platelet activation is highly age-dependent, with rats of advanced age showing a lower response than younger rats.</description><subject>Adenosine Diphosphate - pharmacology</subject><subject>ADP</subject><subject>age</subject><subject>Aging - blood</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood coagulation. Blood cells</subject><subject>collagen</subject><subject>Collagen - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Platelet</subject><subject>platelet aggregation</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1r3DAQxUVpSDZpTzkHFhJ6Kd5q9GHZxyXbtIVAQmjPYiyPHS9eeyNpD_nvI7NmD52DhtH7MW94jF0DX4FQxY9qX63ArCANn9gCpDKZFqA_swUvochy0MUFuwxhyzk3XMhzdm4KwUHAguXrlrIN7WmoaYjLDTlPGGjZDcvnHiP1FJfrtvXUYuzGYfp_wRi-sLMG-0Bf537F_j38_Hv_O3t8-vXnfv2YOZ2rmJlaQVlqobCq68I0tTNGSufqRqPKTV3ydAYq4RrVVCUgOS20ERKVI1Ck5RX7dty79-PbgUK0uy446nscaDwEa_JSpcoTePsfuB0Pfki3WVCqBK1zM1Hfj5TzYwieGrv33Q79uwVupyxtytKCsVOWib6Zdx6qHdUndg4v6XezjsFh33gcXBdOmFQcpDYJ2xyxbYjY0klHHzvX02SZQpKTbTE_yf0ku1f0lgb5AQwNkYY</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>OSHIMA, Kouichi</creator><creator>MORIKAWA, Tadanori</creator><creator>HAGIWARA, Masaki</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Age-Dependent Decrease in Platelet Aggregation in Rats</title><author>OSHIMA, Kouichi ; MORIKAWA, Tadanori ; HAGIWARA, Masaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-7d4199524abdd87fdc7733ccdf5a467d90201a42cf4fb91aec525723a4ce14e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adenosine Diphosphate - pharmacology</topic><topic>ADP</topic><topic>age</topic><topic>Aging - blood</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood coagulation. Blood cells</topic><topic>collagen</topic><topic>Collagen - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Platelet</topic><topic>platelet aggregation</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OSHIMA, Kouichi</creatorcontrib><creatorcontrib>MORIKAWA, Tadanori</creatorcontrib><creatorcontrib>HAGIWARA, Masaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OSHIMA, Kouichi</au><au>MORIKAWA, Tadanori</au><au>HAGIWARA, Masaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-Dependent Decrease in Platelet Aggregation in Rats</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1994</date><risdate>1994</risdate><volume>17</volume><issue>8</issue><spage>1124</spage><epage>1125</epage><pages>1124-1125</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The degree of platelet aggregation induced by ADP and collagen was examined in platelet-rich plasma from 7-to 90-week-old rats. The aggregation induced by ADP was unchanged at 90 weeks. Collagen-induced aggregation decreased remarkably at 60 and 90 weeks. Therefore, collagen-induced platelet activation is highly age-dependent, with rats of advanced age showing a lower response than younger rats.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>7820121</pmid><doi>10.1248/bpb.17.1124</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 1994/08/15, Vol.17(8), pp.1124-1125 |
| issn | 0918-6158 1347-5215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76944446 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Adenosine Diphosphate - pharmacology ADP age Aging - blood Animals Biological and medical sciences Blood coagulation. Blood cells collagen Collagen - pharmacology Fundamental and applied biological sciences. Psychology Male Molecular and cellular biology Platelet platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation - physiology Rats Rats, Wistar |
| title | Age-Dependent Decrease in Platelet Aggregation in Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T03%3A38%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-Dependent%20Decrease%20in%20Platelet%20Aggregation%20in%20Rats&rft.jtitle=Biological%20&%20pharmaceutical%20bulletin&rft.au=OSHIMA,%20Kouichi&rft.date=1994&rft.volume=17&rft.issue=8&rft.spage=1124&rft.epage=1125&rft.pages=1124-1125&rft.issn=0918-6158&rft.eissn=1347-5215&rft_id=info:doi/10.1248/bpb.17.1124&rft_dat=%3Cproquest_cross%3E3120250431%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449155676&rft_id=info:pmid/7820121&rfr_iscdi=true |