Age-Dependent Decrease in Platelet Aggregation in Rats

The degree of platelet aggregation induced by ADP and collagen was examined in platelet-rich plasma from 7-to 90-week-old rats. The aggregation induced by ADP was unchanged at 90 weeks. Collagen-induced aggregation decreased remarkably at 60 and 90 weeks. Therefore, collagen-induced platelet activat...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1994/08/15, Vol.17(8), pp.1124-1125
Hauptverfasser:	OSHIMA, Kouichi, MORIKAWA, Tadanori, HAGIWARA, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology ADP age Aging - blood Animals Biological and medical sciences Blood coagulation. Blood cells collagen Collagen - pharmacology Fundamental and applied biological sciences. Psychology Male Molecular and cellular biology Platelet platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation - physiology Rats Rats, Wistar
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Zusammenfassung:	The degree of platelet aggregation induced by ADP and collagen was examined in platelet-rich plasma from 7-to 90-week-old rats. The aggregation induced by ADP was unchanged at 90 weeks. Collagen-induced aggregation decreased remarkably at 60 and 90 weeks. Therefore, collagen-induced platelet activation is highly age-dependent, with rats of advanced age showing a lower response than younger rats.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.17.1124